Translational control is a major contributor to hypoxia induced gene expression

Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control.

Hypoxia has recently been shown to activate the endoplasmic reticulum kinase PERK, leading to phosphorylation of eIF2alpha and inhibition of mRNA translation initiation. Using a quantitative assay, we show that this inhibition exhibits a biphasic response mediated through two distinct pathways. The first occurs rapidly, reaching a maximum at 1-2 h and is due to phosphorylation of eIF2alpha. Con...

Malnutrition Is Still a Major Contributor to Child Deaths

Malnutrition continues to be one of the world’s most serious development problems. Exacerbating the consequences of infectious disease, malnutrition contributes to about 6 million deaths annually of children under 5. While lowand middle-income countries (LMICs) bear the brunt of the problem, malnutrition affects both rich and poor countries, particularly the poorest in each nation. In developed...

Gene fusion/fission is a major contributor to evolution of multi-domain bacterial proteins

Most proteins comprise one or several domains. New domain architectures can be created by combining previously existing domains. The elementary events that create new domain architectures may be categorized into three classes, namely domain(s) insertion or deletion (indel), exchange and repetition. Using 'DomainTeam', a tool dedicated to the search for microsyntenies of domains, we quantified t...

Control of Tumor Metastasis Perforin Is a Major Contributor to NK Cell

Acutely reduced locomotor activity is a major contributor to Western diet-induced obesity in mice.

The aim of the present study was to investigate the short- and long-term effects of a high-fat Western diet (WD) on intake, storage, expenditure, and fecal loss of energy as well as effects on locomotor activity and thermogenesis. WD for only 24 h resulted in a marked physiological shift in energy homeostasis, including increased body weight gain, body fat, and energy expenditure (EE) but an ac...